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Literature summary extracted from

  • Abell, C.W.; Shen, R.S.; Gessner, W.; Brossi, A.
    Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs (1984), Science, 224, 405-407.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.34 1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0034 mM, 50% inhibition Homo sapiens
1.5.1.34 1-methyl-4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0093 mM, 50% inhibition Homo sapiens
1.5.1.34 1-methyl-4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine 0.27 mM, 50% inhibition Homo sapiens
1.5.1.34 1-methyl-4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.003 mM, 50% inhibition Homo sapiens
1.5.1.34 1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 0.3 mM, 50% inhibition Homo sapiens
1.5.1.34 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0036 mM, 50% inhibition Homo sapiens
1.5.1.34 4-(3',4'-dihydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0072 mM, 50% inhibition Homo sapiens
1.5.1.34 4-(3'-methoxy-4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine 0.34 mM, 50% inhibition Homo sapiens
1.5.1.34 4-(4'-chlorophenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine 0.0059 mM, 50% inhibition Homo sapiens
1.5.1.34 4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus
1.5.1.34 4-phenyl-1,2,3,6-tetrahydropyridine 12 mM, 50% inhibition Homo sapiens
1.5.1.34 4-phenyl-1,2,3,6-tetrahydropyridine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.5.1.34 synaptosome striatum Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.34 Homo sapiens
-
-
-
1.5.1.34 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.34 liver
-
Homo sapiens
-
1.5.1.34 liver
-
Rattus norvegicus
-

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.34 0.0028
-
1-methyl-4-(4'-hydroxyphenyl)-1,2,3,6-tetrahydropyridine noncompetitive inhibition Homo sapiens